Princess Celestia sends Twilight to a human school to learn how to be more human in case another incident happened... but what Twilight finds is that Yokai Academy is nothing like the human world she went to before. Will Twilight be able to return to Equestria in one piece, or will she be overtaken by the monsters at Yokai Academy first?
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I recommend going onto Wikipedia for those of you who have never seen the Anime series Rosario+Vampire. It'll help give you a better understanding of the characters