Twilight Sparkle and Spike in the world of Equestria Girls get trapped in an alternate timeline, one where Chrysalis won.

They will have to escape from there without the use of their magic, where they will have to adapt to a new lifestyle, which will have each other to survive.

After a lab mishap sends the Rabbids to Equestria, the Mane 6 teams up with 6 Rabbids that are dressed like them to explore 4 worlds and stop Chrysalis from misusing the power of Spawny, a Rabbid that has the power to fuse things together.