Part of the All-American Girl continuity.
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For Derpy Hooves, life is never easy. Even as an accomplished scientist and scholar, she still has to contend with a twin sister that hates her, living alone in a tiny town and working a dead-end job, and, of course, her eyes, which causes her to be clumsier in public than she normally is. For her, life sucks.

But now, Derpy has to face a decision that could rock the very foundations of her family, her life and her future. And if that wasn't enough, one of the neighborhood foals, Sparkler, may need her help desperately. And to top it all off, a secret project of hers might just change the world of ponydom forever.

She's got a lot on her hooves. Maybe too much.

While welcoming a foreign dignitary to Princess Twilight's Palace, Applejack refers to the single monarch as "Y'all." This, of course, causes the entire Kingdom of Equestria to explode into flames.

Okay, maybe not explode into flames, but it could happen... right? Just ask Twilight...

Meh.

The wheel of time turns, as destiny and history clash together.

Fifty years into the future, Sunset Shimmer is Princess Twilight Sparkle's most faithful student. She is smart and eager, but doesn't always think things through. Her life had been perfect, right up to the End of the World.

With a ruined future, Sunset travels into the past to alter the course of history. With only her mentor's cryptic word to go on, Sunset and the Elements of Harmony must solve the riddle of the Dark Regalia and stop the mysterious Vesper Radiance from rising to power. But the further Sunset goes, the more she feels like she's been through it all before.

Is destiny set in stone, or can Sunset shape her own future? Only time will tell.

Featured on Equestria Daily 6/16/13
Gratefully edited by JustAnotherTimeLord, Icarus_Gizmo, Cerulean Voice and Bad_Seed_72

The Sunset of Tropes page!

Life in Ponyville, outside of the usual events like a parasprite invasion or a revenge-seeking, all powerful megalomaniac kicking out the town librarian, tends to be laid back and typical. Which Applejack doesn't mind. However, after the CMC cause more problems due to influence from a newcomer in town, Applejack gathers the girls to go fix what the CMC did.

But then a mysterious creature ends up attacking Applejack, and while she survives and seems fine, it isn't long before she starts acting strangely. It's up to the usual group of ponies to figure out what's going on before it's too late.

[img]http://i.imgur.com/6MrWqNZ.png[/img]
*Approved for Twilight's Library on 3/18/14*

Also has a TVTropes page

Princess Luna breaks up with the moon after she catches him cheating on her.

Big thanks to my prereader Majin Syeekoh.

This story is a sequel to A Stitch in Time

Having discovered the message left for her by Star Swirl the Bearded in the distant past, Twilight once again finds herself caught up in the middle of a struggle against forces far greater than herself. In order to even stand a chance she'll need to travel further and wider than she ever has, and forge some unlikely alliances with old enemies. All to bring down the powers that have manipulated and shaped her entire life, and retake control of her own future.

The conclusion of the Time Loop Trilogy, which began with Hard Reset
Available in Spanish thanks to dgs1993
Series TV Tropes page

This story is a sequel to Hard Reset

After the events of Hard Reset Twilight's life and mental well being are slowly returning to normal. Her recovery is cut short, though, when a letter arrives informing her that the time loop spell she cast is causing severe damage to space and time itself. In over her head, Twilight tries to summon anypony who will know how to fix it. The pony she gets is the last one she ever thought she would meet... and nothing like she expected him to be.

Available in Spanish thanks to dgs1993
Series TV Tropes page

Pinkie has a secret. So far, she's kept it from everyone, but Twilight can tell that something's wrong with her. So she offers what vague support she can… until Pinkie takes her into the basement to show her.

Fourth-place finisher in the "More Most Dangerous Game" contest, based on the Cupcakes prompt.

Featured on Equestria Daily!

Given the successful befriending of Discord, Princess Celestia deems that no longer will villains be defeated but instead reformed. While most have the chance to submit willingly or continue to fight, King Sombra is given little option. Brought back from the dead and stripped of all his powers and strength, it's all become a game of futility. Now Sombra only wishes he could have stayed dead all along.

Edited by spigo.

Twilight Sparkle is tired of this nonsense.

Every day, a slew of articles all focused on the minute details of her life invade her beloved newspapers. "Twilight Sparkle Eats Peaches." "Twilight Sparkle Hates Tea." "Twilight Sparkle Uses a Microwave." "Twilight Sparkle Makes Toast." All of it clogging up her precious sources of information from cities across Equestria.

But no more. The time has come to put an end to it, once and for all.

Written with thanks to Marceline from the #FimFiction IRC and for no good reason other than it sounded funny in my head.