A story of how two ponies, both opposites in personality, formed a bond of friendship and love that lasted throughout an entire lifetime...

It's been a few weeks since Luna's returned from the moon, and all is not well. She's become more introverted than ever, rarely leaving her room and obsessing over work. Celestia hopes that studying Twilight Sparkle's Friendship Reports will at least help her get out of her shell, though an unusually talkative servant may just help in that regard...and is anypony else getting strange feelings from that statue out in the gardens?

As of May 4th, now featured on Equestria Daily. *Squee*

Discord has realized the Mane 6's friendship is too strong for him to face head on. He goes back in time to destroy it completely, thrusting Twilight and Spike into an adventure that spans their lifetimes. After discovering that Discord's changes in the past are causing chaos in the present, the only way for Twilight and Spike to fix Equestria is to go back to the future!

*Author's Note*

Be warned, there is going to be some sad and dark stuff in this story, but I don't think it's enough to warrant the use of either tag.

In which I, Twilight Sparkle, (the biggest idiot in Equestria), fail miserably, utterly, and conclusively in my valiant endeavor to keep my decidedly-more-than-Friendship feelings hidden from one Rainbow Dash (the sexiest fastest mare in Equestria).

There have long been elements of unrest in Equestria. A monarch who has reigned for a thousand years will surely be called a tyrant by some. Those who plot Celestia's downfall know the princess herself is beyond their reach, but they can still strike at those she cares for.

After the events of "Secret of My Excess", Spike realizes how much of a danger he really is as a dragon and fears that what he became is what he will eventually become. Not wishing to cause harm to his friends he decides to runaway and leave Ponyville forever....

After Chrysalis failed to conquer Equestria, she was shamefully stripped of her title of "Queen of the Changelings".

Their people now leaderless, the Changeling race now finds itself in a unique situation. In the struggle for power, one Changeling seizes the attention of his people. Can he overcome his nature, and the nature of his people, to lead them into a better future?

One night starless night Twilight attempts to force the stars out using an ancient spell. Equestria now has to deal with another alicorn. Luna is furious, Cadence is estatic and Celestia is curious? Now Twilight finds herself having to leave to prove herself and settle 'the old lands' ponies lived in before equestria. Well she succeed? How much are her friends willing to give up to support her? Answers well be revealed inside.

Twilight Sparkle wakes up one morning to find she's undergone some changes. She shortly discovers she wasn't the only one. (New cover art by Jamey4 on deviantart http://jamey4.deviantart.com/)

Warning, this work of fiction contains multiple fourth wall breaks, massive silliness, and more than a trace amount of alicorns.
The author may or may not have snapped at times in the writing of this work, and it shows. Bring a towel, you may get wet.

Cox:My Little Scrubs!? What an original title! It's- it's like combining My Little Pony and a completely different show into one seamless title! Nobody has ever done that before! Gen-i-us! Must've taken all night to come up with that one, eh big boy? Bets on how long before this is abandoned? Anyone? I've got 5 bits on this lasting three chapters. I know, I know, that's a bit generous, buuuuuut I'm going to give you the benefit of the doubt here.

.... Thanks, Dr. Cox. Anyway, Sacred Heart is a hospital filled to the brim with quirky workers, from the daydreaming sensitive doctor JD to the lawyer sad sack Ted. But when the hospital gets a certain purple pony and her dragon as patients, it opens the floodgates for even more crazy to be let in.

Well, this is going to be my effort to combine two of my favorite shows, Scrubs and My Little Pony. Problem is, I don't know any medicine! So please, along with the usual constructive criticism, please throw out any medicine problem you know, pony, human, or otherwise!