2015.
The angry and broken Sunset Shimmer ("The Demon") and scared and extremely powerful runaway Apple Bloom ("Rogue") are recruited by The X-Mares, a group of "Hu-Mares" with mutations that make them remarkable. But can they save a world that hates them when Discord, The Master of Manipulation, plans to turn the world's leaders into "Hu-Mares"?
1965.
Celestia Aldrich is a "Hu-Mare" with incredible mental powers, a speaker for the rights of her kind, and a party animal who doesn't quite understand the gravity of her fight. Bob Smith is a "Hu-Mare" with the power to bend reality itself, hellbent on revenge against a world that took his mother, took his life, took his soul. These two very different "Hu-Mares" meet and form the first class of the "X-Mares", with the hope of stopping a mad woman from destroying the world, and perhaps of convincing that same world they are not the enemy. But fate may have other plans...