After a tragic accident, a human ends up in Lord Tirek's body, as part of an attempt to reform the villain after his recent escapades. While the hero of our tale is trying to make sense of his new surroundings, the rest of Equestria thinks that the most terrible threat that their world has ever seen is back...
And the powers that be are definitely not happy about it.
New Cover Art By Shadow Bolt

(This fic contains spoilers of varying levels for Saints Row IV.)
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With a full crew of Saints aboard the... Ship and the Simulation all but theirs, Kinzie Kensington and Matt Miller have had surprisingly little to do with their time. Still, with the Boss still putting the Simulation through the wringer, Kinzie has had the pleasure of poking through the Zin's systems at her leisure and looking at what she wanted to look at.

And after a particular urge to check out the Zin's prisoners, she finds a host of different alien species... Including a... unicorn. A unicorn with especially high cyber security. Anything that Zinyak wants to keep safe must be good for Saints. Wary of the ridicuousness of the prospect, the President of the United States mounts a rescue.
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(Featured 12/29/2014! And 01/09/2015! And 02/13/2015! And 02/27/2015! And 08/29/2015! Holy fuck!)

Crossover of BioShock and My Little Pony.

Huge thanks to Dubstep_Teaparty and Sexy Pudgy Pinkie Pie for editing

Scootaloo is an orphan, she has been trying to hide it ever since she escaped the orphanage. After being bullied by Diamond Tiara again Scootaloo whishes she had a big dad to protect her. She is about to get more than she bargained for when the universe decides to bend over backwards for her.

Alpha 9-2 was having a fairly normal day in Rapture until his little sister discovered a strange syringe of Adam. It turns out that one must never inject themselves with a syringe of unstable Adam. No matter how rainbow colored and pretty they are. Now he has found himself in a strange new body in a strange new land and with a strange new little sister.

Holy shit featured 12/5/14 thanks so much!
Asdfghjkl this is getting featured every time I update!

Huge thanks to Shadow Bolt for providing the cover image.