Playing video games, check. Talking with friends, check. Being transported into the lands of Equestria with video game like powers and some evil plot unfolding...uh check.
The Lone Wanderer and the Courier meet in the most unexpected manner, in the most unexpected place, where they meet the most unexpected, colorful people. (May or may not include Evil Toasters, Solar Goddesses, Ponies, and Madness.)
A wacky general store owner and a hardened sniper, both accustomed to the harsh reality of post-apocalyptic life, find themselves in Equestria under strange circumstances. A crossover with Fallout 3 and Fallout: New Vegas.
A mysterious unicorn makes a portal to the Mojave Wasteland, Twilight goes into the portal to investigate. She finds herself in a small town called Goodsprings and a man who calls himself The Courier offered his help.
Courier 6, or Edward, had just left the NCR after aiding them to defend the Hoover Dam from Caesar's Legion, then a portal opened and sucked him in into the world of Equestria, where he meets new friends, go on new adventures, and more.
Twilight Sparkle returns home after disappearing one day, six months ago. The Twilight that came back, however, is different. She may appear strange to her friends now, but her tale is even more strange.
Fluttershy watched the streets of the growing city of New Vegas from the top of her Lucky 38. The Pegasus recalled the last three years since being dumped here by her so called friends, just the thought of the five made the Queen of Vegas frown.