Twilight gets bitten by a spider when she was doing a task for Zecora, then when she was experiencing the symptoms, she goes to the doctor and learns she has a fatal disease and only a week to live.
Rainbow stumbling across Pinkie drinking went a lot better than Pinkie could have hoped, what she didn't know is what would come from it. She thought she was the only one of her friends that was miserable and wearing a mask, she was wrong.
W-what," Pinkie swallowed nervously as she tried to speak, finding her throat was suddenly very dry. "Are you?" It seemed to stare at her for a few seconds, its dark eye sockets peering directly into her soul. "Death."
Mister Lonely Heart is a self-styled "Grievance Counselor", a changeling who mimics ponies that his clients have issues with. When Twilight Sparkle pays him a visit, he finds out how painfully neurotic the Princess of Friendship really is.
Problems are something everyone in Equestria has to deal with, big or small. Some problems have obvious answers, some don't. And sometimes, a pony chooses to deal with their problems on their own, no matter how much help they really want.
A broken-spirited Spike waits for news of Twilight after an accident lands her in the hospital, dancing on the fine line between recovery and the unspeakable.