There are a number of compounds the human body is incapable of synthesizing; these are found only in red meat. To save a dying human, Twilight asks her friends - except for Fluttershy - for advice.
Ivan has a saddle shop in Ponyville, where he sells saddles and saddle accessories. Why ponies buy saddles, Ivan doesn't know, and when he finds out, he'd like very much to go back to not knowing.
A human soul is stuffed into King Sombra's body. Having no idea what's going on, and thinking he is in some kind of coma, he just casually strolls into the Crystal Empire.