After successfully completing another mercenary mission, Deadpool feels that he is living an unfulfilled life. As he flips through his television, he discovers a show called My Little Pony: Friendship is Magic. Deadpool becomes instantly obsessed, and not long after, he starts comparing and contrasting the world he lives in today to the world of Equestria. He suddenly concludes to himself that Equestria would be a better place to live in...

Thrust headlong into a strange new world, Solaire of Astora must make amends before he can continue with his mission. Unbeknownst to them all, a shadow from his past approaches.