Discord wakes up again and this time sends the pony gang to the human world so that they can't ineterfere with his plans. The gang wakes up in the middle of a field and they walk to a small town. They get adapted to human life and make new friends, including boyfriends. After realizing how much trouble Equestria is in by watching MLP, they go on a quest to get back. Will they be able to leave their new friends behind to save the home they love?

A mysterious disease has been spreading all over Equestria turning all kinds of ponies into brain-eating zombies. The disease has reached all over Equestria and threatens to wipe out the pony race. The pony gang, along with the help of Spike, Shining Armor, and Princess Luna, try to figure out how to stop the disease before it's too late. But with friends dropping like flies on either side, will they make it in time?