When a zombie apocalypse breaks out in Equestria, it is up to Rarity, Apple Jack, and the new pony in town (Ginger Melody) to defend the survivors in Ponyville and Canterlot from the ponies that they used to know. When somepony becomes infected, he or she is hardly a shadow of the pony they used to be. Their brains and bodies begin to rot and they turn into flesh-eating monsters who will stop at nothing to take a bite of somepony else.

Twilight and the other Elements of Harmony have saved the land of Equestria from Nightmare Moon, Discord, and the Changeling army, but now they face perhaps their biggest challenge yet. A challenge that lurks behind smiling faces and friendly eyes. A challenge that threatens to overtake the entirety of Equestria and enslave its inhabitants. But the ponies won’t face this threat alone. Help comes in the form of the most unlikely of companions: four teenagers, a hawk, and a blue centaur.