After hearing of a new theater being open in Hope Hollow, Twilight Sparkle and her friends head there, and after meeting the theater owner, who seems to know a lot about their past, present, and futures, they head inside a magic movie screen.

Next thing they know, they end up meeting a pessimistic boy who seems to have a fear of everything and runs his life based on safety statistics. Together they went to the library, where they will embark on an amazing adventure.

The various experiments from Lilo and Stitch arrive through a portal created by 628. Now, Twilight and the main 6 must find each experiments "one true place". But other things have come through too. Can the experiments be saved before Jacques Van Humsterviel steals them all, and destroys Equestria?