After volunteering as the first test subject for Twilight's spell, Applejack finds herself trapped aboard the USG Ishimura. With her only help being a human named Isaac Clarke, she fights against nightmarish abominations to make it home alive.
Taylor Harding is put on a whirlwind of an adventure. Isaac Clarke and this man find themselves on a strange planet where necromorphs followed them. It's up to them to find the new source of infection and end it.
During the ending of Dead space 2, Ellie makes a risky attempt to save Isaac from dying, but in vain as Isaac sacrifices himself once more to save Ellie. At least he thinks he sacrifices himself until he is brought to another world.
Luna has been plagued by visions of an apocalyptic future, ruled by necromorphs. There is hope, Luna has also seen a creature able to effectively slay the necromorphs, As well as destroy their markers. Problem is, will he help them?