My personal picks would be:
1.Fluttershy abd Rainbow Dash
2. Pinkie pie and Minuette
3. Luna and Twilight
4. Cloudkicker and Sunshower raindrops

7779382
Id cuddle Chrysalis and Fluttershy.

1. Twilight and Sunset Shimmer (Pony)
2. Luna and Rarity
3. Starlight Glimmer and Trixie
4. Pinkie Pie and Applejack
5. Rainbow Dash and A random Changeling (I ran out who I want to cuddle with.)

7779382
Well, I'd have to go with Fluttershy and Pinkie Pie for sure.

Izzy and Pipp.

Fizzy and Morning Glory.

And while this is cheating, the CMC.

7779382
Fluttershy and twilight sparkle

Buuuut.... since you chose 4-
Parasol, and rarity- scratch that, ALL THE FUCKING PONIES

Rarity and Luna

Luna and Twilight

Ruby from Story of the Blanks. She's the pony in my thumbnail.

If not her, then the following.

Princess Luna
Moondancer
Photo Finish
Stella Flare (hottest milf)
Starlight Glimmer
Marble Pie
Songbird Serenade
Adult Apple Bloom
Vinyl Scratch
Silver Spoon Adult
Glisten Sheen Adult (an OC bat pony in my story family facade)
Spitfire
Lyra Heartstrings
Wild Flower/Flowershine
Ditzy Hooves
Adult Ginger Snap
Apple Fritter
Cheerilee
and one of the mane 6?.........

Hmm.....Rainbow Dash. She annoys me but I cannot see myself cuddling with any of the rest of the mane 6. All mares listed here are mares I would marry and breed with.

1. Fluttershy and Celestia
2. Nurse Redheart and Mage Meadowbrook

One of the pairings is bound to find a cure for me.

Twilight and Fluttershy mostly because they would most likely allow me to. Plus my fav pony Pinkie probably wouldn’t stay still long enough to cuddle without trying to make it into a game or something.

1. Fluttershy and twilight sparkle
2. Ditzy Hooves and Starlight Glimmer
3. Pinkie pie and Marble pie

Together?

First thought is Fluttershy and Derpy.

Luna and Nurse Redheart.
Coco Pommel and Rarity.
Trixie and Twilight.

All, No matter who would comes for cuddles.

Diamond Tiara and Silver Spoon

Celestia and Luna, obvs

Starlight Glimmer and Tempest Shadow

Scootaloo and Rainbow Dash

Chrysalis and Fluffle Puff

Nightmare Moon and Daybreaker

Nurse Redheart and Cheerilee

Derpy and Dinky

I think those are my top pairs.

Rarity and Octavia

Sunset Shimmer and Flutterhshy.

Tempest Shadow and Nightmare Moon.

Luna silver spoon Scootaloo and the kicker twins

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1. Fluttershy and Twilight
2. Starlight and Twilight
3. Starlight and Trixie
4. Rarity and Twilight

Pinkie and Starlight
Fluttershy and Luna

Princess cadence and nurse redheart.