Former research biologist who now spends his time dissecting electronics and rolling around in poison ivy.
I have a PAPER!!
Gentlemen.... BEHOLD!! I HAVE CREATED MUTANT MICE!!
https://www.ncbi.nlm.nih.gov/pubmed/31869353
And now to use this knowledge for evil! MUWAH HA HA HA HA!! (cancels out everyone's BMPs on Twitter, via 4chan.)
Page generated in 0.05 seconds
Total duration
976 users online
1,460,350 hits today, 2,073,628 yesterday
My Little Pony: Friendship is Magic Fanfiction
Designed and coded by knighty & Xaquseg - © 2011-2024
Support us
SubStar
Chat!
Discord
Follow us
Twitter
MLP: Friendship is Magic® - © 2024 Hasbro Inc.®
Fimfiction is in no way affiliated with or endorsed by Hasbro Inc.®
Welp, we're doomed
Congratulations, and allow me to say here and now that I for one welcome our future rodent overlords.
5182388 Soon, my army of Nayzee rats will RULE THE WORLD!! Once we get rid of that damned Nutcracker....
Congratulations. :)
Can you explain what it says in layman's terms? I love science, but don't understand it.
congratulations!
HA HA KNOWLEDGE
5182565 We mutated these signaling proteins in embryonic mice and it made parts of their brains go away because another protein was like "Oh, I can express all the up to the top now! Cool!"
And that made this one type of neuron basically not exist, so no cerebellum or pons.
5182808
Cool.
Congrats!
Lol the biggest suprise of all is that your actually a scientist irl
haha didnt see that coming.
Nice job mate
Congratulations!
And somehow the people downvoting all your fanfictions will manage downvote your research.
Anyway what is the purpose of all this? To understand how the developing of certain parts of the brain works? Or there is something to gain in not making the cerebellum or pons not grow? Will you lose your ability to like ponies?
5182950 There are several rare syndromes that feature similar anomalies in the hindbrain, and some people are born without a cerebellum.
We uncovered a central developmental genetic pathway which is likely at the very least centrally involved, and is probably directly causal in all those syndromes.
Once you have most of the pieces of what genes are required to form a certain structure, it becomes much easier to determine which one is mutated or being interfered with expression-wise in a birth defect or simply unusual physiology (interestingly, about 9 known people born missing a cerebellum have very mild symptoms, versus most others with profound disability death in childhood. How the mild symptomatology occurs in some cases is not known. Some other part of the brain somehow compensates for the absent structure.)
A woman born without a cerebellum AND pons! https://www.newscientist.com/article/mg22329861-900-woman-of-24-found-to-have-no-cerebellum-in-her-brain/
Compare her brainstem (top CT image) to the CT to the normal brain (lower scan) in this article. The feathery/fern-like structure on the right of the brainstem in the normal brain is the cerebellum. Note that her scan shows an empty space. Now, look to the left on the normal brainstem, directly opposite the cerebellum. That oval bump? That's the pons. Compare to her brainstem... NO PONS!!
Our paper outlines the genetic pathway that almost certainly was involved. The BMP signal or the genes downstream of them which are critical for mossy fiber formation have been dysregulated or rendered dysfunctional. Since the BMP genes are also crucial for limb formation, and she had normal limbs, we can assume it's most likely one of the other transcription factor genes our lab noted in the paper which suppress the advancement of the ventral rhombic lip primordial structure Ptf1a, namely: Atoh1 and Wnt1; as well as Lmx1a (noted in another lab's paper to similarly reduce non-Gdf7-positive roofplate, Gdf7 being an embryonic lateral roof plate marker gene).
5183168
Wow. Again, congratulations to you and all of your collegues!
So what are you trying to do exactly?
5184548 Aside from creating Daleks to rule the universe?
5184905
Make gryphons. They're more cuddly
But what exactly are you trying to accomplish here, I mean. Paint me a word picture!
5184950 There are a number of applications, from understanding how progenitor cells differentiate into these adjacent tissue regions and keep themselves as the proper cells types despite different signaling going on literally one cell away.
But the primary focus is seeing if there's a potential for treating osteoarthritis and in joint regeneration. Close to that, there are several developmental syndromes we're looking into which have an unusual combination of skeletal and neurological symptoms. The several Sox genes are mutated and we're studying how the mutations lead to the syndrome.
5182410
You're using rats!
But... but we need them for pretentious schlock so Cutt can feel like he's being profound
5186237 My lab is using mice.
Rats will be for the genetically-engineered army. They're bigger. They can carry bigger bombs!
5186263
Insert Steven Cutt joke here.
And aren't aren't rats just fat ass mice, like a squirrel is just a rat with good PR?
5186271 They do have other differences. Rats are a good deal smarter than mice, live about twice as long, and can form friendships with pigs and talking spiders.