GLaDOS, the one powerful AI that ran the Aperture Science Enrichment Center, has been turned into a young Equestrian after being tossed in a realm where true science is unheard of and Magic is the primary factor in the advancement of civilization. As she matures, she'll experience normal everyday occurrences like saving the world from invading xenos, preventing a disastrous outbreak, over-throwing the current ruler of the throne, and other various things. No biggie, right?
So who is ready to do some science? And make 60 bits? Cash.