The Albinocorn wrote Anamnesis, which is a delightful tale of star-crossed lovers who are separated by cruel fate and have to live with it. Twilight isn't the sort who's first response to a problem is "acceptance", and she is not without people she can ask for help.

These are her failures.

Probably doesn't make a lot of sense without reading the original first but the short version is Pony!Twilight and Sunset have loved each other across the millennia via serial-reincarnation. They have been cursed for their romance to end in tragedy and to dream their past lives and their frequently horrific endings. They try defying fate for a bit but give up when it looks like there will be collateral damage.

You struggle to find meaning in a mechanistic universe. Like sisyphus before you, you are chained to purposeless striving whose only release is death. The process the called "living".
One day you wake up in a magical land full of talking ponies. This makes essentially no difference.

"Pretentious" -DarthSonic66

Gödel, Escher, Bach: An Eternal Golden Bridle: An intersection between the set of pony fiction and the much smaller set of GEB fiction; Mr Tortoise engages in some applied meta-cognition with Rainbow Dash, fleetest of wing of all mortals.

Dear Princess Discord: Twilight writes to her other mentor. (Princess Twilight Sparkle/Daring Don't)