More an adventure than a comedy, but when the CMC is involved, you know funny stuff will happen.

Scootaloo is the daughter of Lyra and Bonbon. Except she isn’t really. She’s adopted.
Scootaloo has only just figured this out after Miss Cheerillee’s brief explanation of sexual education.

She and the other crusaders set out on a grand quest to seek out Scootaloo’s mother. Getting into all sorts of scrapes along the way.

Twilight and her five friends are transported during a botched spell, across dimensions to... Ponyville, Equestria? But not the same one that they knew. Sitting on a bench is Harpsy and Babar. The Doctoress avoids apples from an aspiring Applebuck. And in a library across town, six stallions join their forces as they try to decipher the appearance of filly look-alikes of themselves around Ponyville!