A pony named Dex creates a resurrection potion that goes wrong. The mane 6 have to find his lab to get the antidote and save everypony, but it's not easy to do.

The Doctor arrives in Ponyville where he meets 2 mares: Derpy and Carrot Top. They follow him around as he explores and they even help him defeat Daleks that invade Ponyville and threaten lives.

Equestria, 1000 years ago. It is dark, cloudy and everypony is living in fear of their ruler. But two ponies in particular have caught the dictator’s eye. This dictator has the former rulers, Princesses Celestia and Luna enslaved in his lair. This dictator: Discord, God of Chaos. These two ponies: Silver Lining and his younger sister Silverfish have formed a Rebel Alliance against him to which Silver Lining is the leader. Discord wants any ponies that are against him caught and arrested and enslaved or killed. Silver Lining and his Rebels have yet to actually fight Discord because they are always slowed down or stopped by his guards. The Rebel Alliance consists of former slaves that Silver Lining rescued. They have their headquarters in a little shack outside the White Tail Woods. This will be a long battle for freedom and rescue the rightful rulers of Equestria, but the Rebels are ready…