A young mare named Melody Bloom loses everything to the harsh world and feels that everyone is against her, she does everything in her power to survive against all odds.

Twilight gets a letter from someone during Hearts and Hooves day so she goes to find out who it's from.

The kingdom is under attack by a new enemy, the girls get separated. Twilight runs into a girl from 4000 years in the past who seems to know Celestia and Discord. with Ponyville gone and the monsters hunting each of the girls there isn't much room for hope.