The Titans will be escape soon, Equestria will be destroy. Most of the Gods are only take care of themselves only. Zeus, Hades and Poseidon get captured in the Underworld. Only the Royal Sisters who can save them.
When Humanity met Ponykind, things went poorly for humanity. A Unicorn named Prancer travels back in time, and sets out to solve the "Human problem" with a magical virus that'll "take the evil out of Humanity". What could possibly go wrong?