A quick note, this will not include characters unique to the Foundation and AWE storylines, as I haven't played the DLC yet, I've only just finished the main storyline and am trying to decide which DLC to do first. I might also miss a few side quest characters, and I'm not sure I've gotten them all. With that out of the way:

Emira Blight as Jesse Faden.

Wallflower Blush as Emily Pope.

Agent Texas as Marshall.

Tony Stark as Dr Darling.

Hank Anderson as Langston.

Asami Sato as Arish.

Master Oogway as Ahti.

Azura (Elder Scrolls) as The Board.

Savathuun as The Former

The Traveller as Hedron/Polaris

Shia Labeouf as the Hiss.

Miranda Lawson as Former Director Trench.

Edric Blight as Dylan Faden.

The TARDIS as The Oldest House.

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This is, like, the third recast meme in a row! What the heck? Did I just jinx something?