On their second Unity Quest, the Mane 5 and Misty meet Mystery Incorporated for the first time and help them solve a caper on Moonscar Island going back over 200 years... all while Opaline lurks in the shadows with her own scheme in mind.
The Pippsqueaks, hoping to get away from their own problems at home, join the Mane 6 and Mystery Inc on a mission to save a historical summer camp, haunted by spooky stories of the past.
After finding the legendary realm of Skyros and Sunny's mother after such a long time, the Mane 6 are called to the city of Danville to help Phineas, Ferb and all their friends save the Tri-State area from an other-dimensional Dr. Doofenshmirtz.
After a strange spell is cast by the Unity Crystals, the Mane 5 and Misty must help the Warner Siblings retrieve a magical wishing star from a greedy king and save the kingdom of Warnerstock from poverty.