There are several classes of antifungal agents, including:
Azoles: These are among the most commonly used antifungal drugs. They work by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. Examples include fluconazole, itraconazole, ketoconazole, and voriconazole.
Polyenes: Polyene antifungals bind to ergosterol, disrupting the integrity of the fungal cell membrane and causing leakage of cellular contents. Amphotericin B is a well-known polyene antifungal often used for serious systemic fungal infections
Echinocandins: These antifungals inhibit the synthesis of beta-glucan, a major component of the fungal cell wall, leading to cell wall disruption and fungal death. Examples include caspofungin, micafungin, and anidulafungin.
Pyrimidine analogs: These antifungals interfere with DNA and RNA synthesis in fungi. Flucytosine is a pyrimidine analog often used in combination with other antifungal agents for the treatment of serious fungal infections
Topical antifungals: These are antifungal agents applied directly to the skin or mucous membranes to treat localized fungal infections. Examples include clotrimazole, miconazole, and nystatin.
It's important to use antifungal medications as prescribed and for the full duration of treatment to ensure the infection is completely eradicated and to prevent the development of drug-resistant fungi.