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Tapentadol is a prescription medication used to treat moderate to severe acute pain. It is an opioid analgesic, but it also has some properties of a serotonin-norepinephrine reuptake inhibitor (SNRI). Tapentadol is primarily prescribed for the relief of acute pain, such as pain following surgery or injury. It can also be used to manage chronic pain in certain situations. Tapentadol works by binding to mu-opioid receptors in the central nervous system, which reduces the perception of pain. apentadol has a unique mechanism of action compared to traditional opioids. In addition to its opioid effects, tapentadol also inhibits the reuptake of the neurotransmitters serotonin and norepinephrine.