Primary insomnia has been viewed as a symptom of mental problems and now it is commonly viewed as a behavior issue. However, evidence has shown that primary insomnia is associated with activation or pathology in the entire body and brain metabolic systems, the cardiovascular system, and the endocrine system. Data have shown the appearance of pathophysiology before and leading to the improvement of changes in cognitive and mood function. Pathophysiology has also been appearing in an animal model

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