I'm not entirely sure about the story, but I think it starts off as a mysterious World of Goo Corporation starts extracting wild slimes to sell products, and the goal is to use them to build structures that lead to the pipes. There's plenty of different species of slimes with different attributes and it is very atmospheric for a game only made by two people relying on a coffee shop wifi conection.

Do you think you can imagine a similar situation poping up in Equestria?

I think this were a direct crossover, I bet either Flim and Flam or Diamond Tiara's mom would own the corporation. But aside from a crossover, what do you think of the concept of slime ponies combining to make large structures or corporations trying to use slimes for their own personal gain?

5225402 Not a bad ideal

But I would want to see that as ponies, before.
p.s. Yes, I know it's not Goo-Ponies