I think since this is going to be a different take on the series in which Twilight stays friends with classmates from the school, if Twilight’s tower is destroyed by Tirek then the Tree of Harmony should create her new castle on the side of her old home.

Likely, but I would also make so it's adjoining Canterlot castle almost like an extension, it would make it more convenient for episodes inside the place and with other princesses.

7721684
Now that is a great idea. Cause I was thinking it should eventually be close to Princess Celestia’s castle where Twilight Sparkle’s tower used to be.

7721688
Hello! What about Equestria Girls story idea in Canterlotverse?

7749001
That depends if someone will do the Equestria girls Canterlotverse. You must speak with the user that founded this group to submit story ideas for this universe.