Colgate wakes up one day to see that her entire stock of toothpaste has somehow flooded her house! She can't teleport, so she has to get out of her house to ask Princess Twilight for help, which is easier said than done.
But maybe Twilight is a bad idea.
And Pinkie Pie.
And basically everypony in Ponyville.
Oh buck.
Absolutely hilarious insanity. At least Colgate doesn't need to shower with soap. She's minty fresh now!