After receiving a request from Braeburn, Big Macintosh makes his way to Appleloosa to help his cousin in his time of need. The visit is shadowed, however, by Big Mac's lingering resentment over an issue Braeburn doesn't see quite the same way. Underneath the blazing desert heat, they air their differences, and discover what the idea of 'family' really means.

Applejack receives an apology from her big brother.

After a discussion with Rose and Daisy, Lily's anxiety becomes the subject of discussion, and her two friends convince her to take medication for her anxiousness. In a fashion befitting her anxiety, she worries unduly and overdoses, and experiences a variety of hallucinations as a result, leading her on a bizarre journey through Ponyville.

Luna struggles with the edges of sanity and feelings of depression after her time of lunar isolation.

Pinkie confronts the fear of losing her friends as she tangles with the dark of her subconscious inside her own mind.

Pinkie Pie organizes a "we're sorry" party for Zecora in the Everfree Forest; things go great until an unexpected surprise shows up...