Twilight Sparkle’s had enough of Anon’s pranks, so she gets back at him with one of her own: each time he uses foul language, he becomes more of a cute pony.
Humankind’s self-destructive tendencies lead to global catastrophes and wars over resources. When survival is far from guaranteed, surely receiving aid from a reformed spirit of chaos would be better than no aid at all.
After learning about zap apples and how the jam was made, Twilight Sparkle’s curiosity is piqued by the Timberwolves, one of the few things that she had any hope of understanding, and decides to investigate.
First, those affected acquire an unhealthy obsession with cartoon ponies. Second, they begin to see their large, colorful eyes in their vision, like spots. Finally, those eyes roll shortly before the afflicted disappear.
After being ejected from Canterlot, Chrysalis decides to risk expending some of her changelings in search of greener pastures, in order to hasten their recovery and try to conquer Equestria again.
The process and results of experimentation can be problematic or dangerous in terms of safety and disposal. Thanks to the convenience of dimensional portals, however, problematic and dangerous experiments can be easily dealt with.
When Discord gets turned into stone the second time around, the Tree of Harmony, now older and far more developed, takes the opportunity to reform him.
A human discovers a strange book in a library, where an animated, purple pony appears on every page with the purpose of teaching friendship and solving friendship problems.
Anon's immune system wasn't prepared for the various maladies found in Equestria and nearly perishes. He eventually gets to choose how to move forward while a way home is found, although nothing's ideal.
When Twilight Sparkle learns that her assignment to make friends is the most essential one, she has a panic attack that results in a magic surge, one that puts her in a time loop.
Pinkie Pie has been aware of the audience watching her world and its ponies, and now she has the time and opportunity to throw parties for said audience. And sometimes she comes bearing gifts.
Luna takes a trip to familiarize herself with Equestria's advancements, as well as places that had not been settled a millennium ago, and discovers something that requires an explanation from her sister.
Before going to Ponyville, Twilight Sparkle connects more dots than usual, which gives her more reason to face Nightmare Moon alone. (Pamphile (PAM-feh-lee) means "friend of all" in Greek.)
Marshall is in a rut, drifting without a purpose. Rarity is in a rut, looking for inspiration. By chance they meet, despite living in different universes, and find what they're yearning for with the aid of the other.