After discovering that Cadence is not who she appears to be, Twilight is sent to another world entirely by the disguised Changeling Queen to avoid her plan being disrupted.
When Twilight lands, she discovers that not only have Spike, Owlowiscious and Peewee followed her, but that they've arrived in a world where the main sentient species is human.
There's still a place where they teach magic, though.
Crossover with Harry Potter. Twilight will be effectively taking the role of Hermione.

I've marked this story as cancelled to reflect the unlikelihood of it continuing. If I do come back to it I'll revert that.

Spike wakes up on the side of an unfamiliar road, with only a confusing memory of the night before and a very unspecific note in his hand. Following the road, he finds himself in the town of Dragonsville, a rural town in the direct center of the country of Serpentia, land of love, tolerance, and harmony. Upon entering the town, he comes face-to-face with the most confusing group of dragons he's ever met: Pinkie Pie, the baker; Rainbow Dash, the stunt flyer; Applejack, the farmer; Rarity, the designer; Fluttershy, the animal enthusiast; Twilight Sparkle, the librarian; and Spike, the #1 assistant, who also happens to be a unicorn, a species most rare in this land.

And so begin the most incredible two weeks of Spike's life...

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Featuring Brand New Cover Art by Ms. Pia-Sama!
MLP: FIM Characters, Settings, etc. © Hasbro & Lauren Faust