Yeah. Me and a friend of mine *cough*Perception filter*cough* have been playing Civ V a lot and out of all the time we've spent playing, there's one thing that we've discovered that's very important.
Gandhi is an expansionist and needs to be wiped off the face of the planet as soon as you're able to destroy him. If you don't, he'll take your land, spread his religions, and eventually be a dick and declare war on you.
Also: Never say yes to one of Gandhi's peace treaties.