After another stunt gone wrong, Rainbow finds herself cooped up in a hospital room again. But when she ends up getting roomed with a nine-year-old colt, her stay at Ponyville General takes a turn she could have never seen coming.
For Twilight, the increased lifespan that came with princesshood had forced her to outlive her friends, but thanks to Rarity, she will learn that centuries could be lived in but a single day.
Three old friends join Fluttershy at her cottage for her 60th birthday party, and afterwards, Fluttershy walks Applejack home. On the way they stop and visit a departed friend.
When Twilight reveals that using the Elements has left her and her friends incapable of bearing foals, each of them must learn to adapt to this heartbreaking reality.