The queen of changelings, Chrysalis, wakes up after a long hibernation that lasted for 2 centuries to discover that everything has changed. She doesn't know what happened and soon discovers that this new world is extremely hostile. She will find ways of surviving without a proper love source and hopefully find out how it all happened and why. She will meet allies along the way and some old enemies from the past. These enemies soon become allies with trust issues and eventually friends. Chrysalis will soon find this new world as home.

Fallout/My Little Pony Crossover
Set with Fallout 4 mechanics

After the events of "A Canterlot Wedding," Queen Chrysalis is about to die, after having been flung hundreds of miles away and through an apartment roof.
Bold Words is the owner of said apartment, a struggling author who always wanted an epic adventure of his own. When Public Enemy Number One comes falling (literally) into his life, near-dead, helpless, and in dire need of assistance, will he be able to resist his adventurelust and do what any good citizen should do?
Or is he going to do something ill-advised, incredibly stupid, very dangerous, and ADVENTUROUS?
Most ponies that know him would take heavy bets on the latter. Too bad for the changeling queen.
(Thanks to Yula568, or Elia Vraay, for the cover art from her DeviantART Page.)