The Titans' Orb is a magical stone created by the Titans of Harmony to protect Equestria from otherworldly threats. After a vengeful demigod breaks loose from Tartarus, the Orb is shattered into six pieces and sent to Planet Earth, scattering across the globe. Twilight and her friends are sent to retrieve it at once, for all of Equus is now in grave danger.

Meanwhile on Earth, there lives a boy named Callum, recently fatherless and enduring the torment of an abusive family. He is soon to discover that the fictional characters from his beloved T.V show, are not so fictional.