It's a big list. No giving me a hard time if you disagree (or anyone else who posts their FD lists), but you are free to ask why if you are curious.

(If you don't know what that means, it means saying in your headcanon that it never happened in that fictional universe)

1. 24 - Seasons 7 and above
2. Alien 3 and Alien Resurrection
3. Avatar - Anything past the first film
4. Batman & Robin
5. Blazing Dragons - Merle's Mirror, and Three Dragons and a Baby
6. Bones - Seasons 11 and 12 (of course The Resurrection in the Remains is canon to Sleepy Hollow)
7. The Boondock Saints II: All Saints Day
8. Curse of Chucky and Cult of Chucky
9. DC Animated Movie Universe - Justice League Dark: Apokolips War. (Also for the moment will only focus on Batman: Hush, but not FD any of the rest before Apokolips War)
10. Detention - Boyz 'N the Parenthood
11. Die Hard - Live Free or Die Hard, and A Good Day to Die Hard
12. Digimon Adventure Tri
13. Digimon Tamers movies (if they were ever canon)
14. Dracula (Hammer) - Scars of Dracula
15. Dracula (Hammer reboot) - The Satanic Rites of Dracula
16. Dragon Ball Super
17. Escape From LA
18. Final Fantasy VII - Anything outside of the original game
19. Final Fantasy XII: Revenant Wings
20. Final Fantasy XIII - Anything outside of the first game
21. The Flash Season 5, Legends of Tomorrow Season 4, etc. (Mainly due to the crossover stuff depending on you having seen ALL the shows being too much, and not explaining Reverse Flash's return; I respect Legends S4 for having decent brony representation)
22. Ghostbusters: Afterlife
23. Hannibal - Red Dragon
24. Highlander II: The Quickening
25. The Hunchback of Notre Dame II
26. Incredibles 2
27. Independence Day: Resurgence
28. Indiana Jones and the Kingdom of the Crystal Skull; Indiana Jones and the Dial of Destiny
29. Inspector Gadget 2
30. John Wick 2 and above
31. Kirby - Heroes in Another Dimension (sub-mode of/sequel to Star Allies), the mode with Leongar in Forgotten Land (even though he is established to survive already, like HiAD it's too hard for non-professionals)
32. Lethal Weapon 4
33. Lord of the Rings - The Hobbit (similar events must have taken place in Lord of the Rings canon, but not in the way depicted in the films)
34. Mario – Super Princess Peach (game was not fun and unresolved plot point with Perry, nothing to do with Peach being main character, the concept had great potential)
35. Mario & Luigi: Paper Jam (not out of dislike, might just go by as a standalone game later, just doesn't fit in)
36. Marvel Cinematic Universe - Anything Post Endgame EXCEPT Spiderman: Far From Home, Spiderman: No Way Home, Guardians of the Galaxy Vol. 3, and The Marvels. (And I won't even dignify the TV series that pretend to be MCU with mention on this list, exception being Loki which I hear was good)
37. Matrix: Resurrections

38. My Little Pony: Friendship is Magic episodes:

    • Somepony to Watch Over Me
    • Princess Spike
    • Once Upon A Zeppelin
    • Grannies Gone Wild
    • Non-Compete Clause
    • Yakity-Sax
    • On the Road to Friendship
    • Going to Seed
    • She Talks to Angel
    • Growing Up Is Hard To Do

39. Also, for Equestria Girls: ANYTHING EXCEPT:

    • Equestria Girls
    • Rainbow Rocks
    • Friendship Games
    • Legend of Everfree
    • Monday Blues
    • Pet Project
    • Epic Fails
    • Forgotten Friendship
    • The Other Side
    • Game Stream
    • Street Chic
    • I'm On A Yacht
    • Let It Rain
    • Do It For The Ponygram
40. G5 - Secrets of Starlight, Tell Your Tale
41. The Neverending Story 3
42. Once Upon A Time – Season 7. (I'll say any hints in S6 finale are a dream sequence)
43. Paper Mario: Sticker Star, and Paper Mario: Color Splash. Maybe Origami King as well, I consider the first three a trilogy
44. Pirates of the Caribbean: Dead Men Tell No Tales
45. Pokemon - Holiday Hi-Jynx and Snow Way Out
46. Rush Hour 2 and 3
47. Saw - Jigsaw and Spiral
48. Shrek Forever After

49. Sonic games:

    • Sonic the Hedgehog 4 Episodes I and II
    • SegaSonic the Hedgehog
    • Tails Adventure
    • Knuckles' Chaotix
    • Sonic Labyrinth
    • Sonic the Fighters
    • Sonic R
    • Sonic Free Riders
    • Anything after Sonic Forces (well, I will say they are in a separate timeline where the Rivals games never took place)
    • If Sega says the IDW comics are canon, then I FD that as well. Besides, they haven't even read them because there are unexplained inconsistencies.
50. Star Fox Command
51. Star Trek films - The Final Frontier, The Undiscovered Country, Nemesis
52. Star vs. the Forces of Evil - Anything past The Battle for Mewni
53. Star Wars – Any TV series aside from MAYBE Mandalorian. Also Solo. (Sequel trilogy I say takes place in a parallel universe)
54. Street Sharks TV series
55. The Swan Princess Christmas and everything after
56. Teen Titans – Season 5
57. Terminator - Anything past the second film
58. The Three Musketeers (1973) - The Return of the Musketeers
59. Transformers: Age of Extinction and Transformers: The Last Knight
60. Willy Wonka - Snowpiercer
61. Wonder Woman - The rest of DCEU
62. Wreck-It Ralph - Ralph Breaks the Internet
63. Xenoblade Chronicles 2
64. X-Men films - Dark Phoenix, Logan
65. The Legend of Zorro