When Deadpool ends up in Ponnyville due to a teleporter malfunction, he must figure out a way to fix it before the changelings can use it to go to earth, and he'll need all the help he can get, but until then Deadpool explores the new world, freaking out ponies, and having plenty of fun.

When a man named Jack ends up in Ponyville through a time travel mishap, he must get help from our favorite six ponies if he hopes to ever make it back home. And things get a bit interesting when the changelings try to thwart his plans.