SPOILERS for the 9th Season
First she was defeated in Canterlot, then she lost her hive and finally the clones she made of the ponies who ruined her life turned on her and got turned into pieces of wood. Chrysalis hasn't had the best luck ever and when things couldn't get worse, she finds out that Twilight and her friends will soon be the new rulers of Equestria.
Seems that nothing will ever go her way, but it will all be worth it soon, hopefully. All she can do is come up with the next plan and it all starts with a mysterious journal she found in the Everfree Forest.