See No Evil.

Hear No Evil.

Speak No Evil.

Residents of Equestria wake up one morning only to realize that they have lost their ability to either see, hear, or speak. Everypony is afflicted, including Twilight and her friends.

This occurs during the same instant that Canterlot Castle loses contact with Mizaru, Kikazaru, and Iwazaru--The Wise Monkeys from the East.

Surely... this can't be a coincidence?