This takes place after the non-canon Evil Karma ending of inFamous 2

Conduits. People with superhuman abilities, ranging from manipulation of a certain form of energy or matter, to flight, enhanced senses, and strength or other physical enhancements. Once a simple bike courier, Cole MacGrath, was one of them. He possessed immense control over electricity, boasting the ability to summon a gigantic bolt of pure lightning from the sky.

After defeating Kessler, who later revealed he was Cole from an alternate future and told him about the Beast, a powerful Conduit who threatened all of mankind. One month later after, Cole met up with NSA agent, Lucy Kuo. Kuo knew of "the Beast" and in fact, found Cole to help him prepare to fight it. She knew only one person who could help Cole combat the Beast. Dr Wolfe. He was one of the many scientists who helped make the Ray Sphere and had made an anti-Ray Sphere titled the Ray Field Inhibitor. The device, however required the power of seven Blast Cores. Cole, with this knowledge, headed out to go find them.

It was then later revealed that the Beast was a old friend of Cole named John White. He was unable to kill John because he simply did not want to and sided with him when he told him he could activate Conduits. In the end, he was forced to kill one of his friends, Nix and Zeke - his closest friend who stuck with him even in the darkest times. A month later after his death, regret fills his broken heart and gives way to depression.

However, due to an odd colored Blast Core that he and Kuo found in the wall, he ends up in another world with Zeke. This world is cheery, colorful and filled with technicolor ponies. Shit.