Dr. Zalost isn't happy. He has tried to reach the goal of unconditional joy and bliss, even temporarily achieving that happiness with the help of a certain pink coated dog, but the good doctor has once again fallen into a depression that has started to eat away at his mind and body, the same depression that threatened to turn Nowhere into a dark and melancholy wasteland.

Now Dr. Zalost has cast his despondent gaze upon Equestria, where love and happiness flourish, and joyful laughter is law. With new weapons of disconsolate sadness, and the determined objective to see everyone just as unhappy as he is, the doctor now plots a nefarious scheme to bring about Equestria's total condemnation of all things benevolent.......and a certain pink coated pony may be the only one who can stop him.

Crossover between Courage the Cowardly Dog and My Little Pony: Friendship is Magic.