300 years later....
Pony and human relations are better than ever before. There was once only trade between the two races, but now it can truly be said that they are friends. Both sides have gained much knowledge. Ponykind has learned of the larger side of science, the study of stars and galaxies, while humans learned much about subatomic physics (through magic, technically a form of nanotechnology).
Princess Twilight Sparkle Sat upon her throne and reflected these developments. She remembered the day humans had first contacted them. It is was entirely unintentional, and surprising to both parties. It was both mind blowing and completely logical when Twilight revealed that they had met before.
Spike was just a baby then. Twilight smiled at the memories of her of her friends. Applejack as old as Granny Smith had ever been now. Rainbow Dash was the most respected member of the Wonderbolts, only ever training the best of the best. The others lived life as they always had, even getting marriedd and watching their kids grow up.
The humans were different. One generation would last only about 100 years, though that number slowly grew. It really was amazing how two races so different, yet so similar, could form friendships across the galaxy.
As was said in the golden record,
"We step out of our solar system into the universe seeking only peace and friendship."