"FUCK IT! YOU FILLIES TALK TOO MUCH!" Celestia roared, above the general din. The dull roar of daytime hospital operations subsided in the wake of the far-from-regal proclamation, as ponies across Equestria stood awestruck at the Princess's rage, but the noise was soon replaced by another, more sinister sound.
Rushing wind, roaring like an oncoming train, tore the windows from the Institute as a gray funnel formed around the building. The tornado rocked the hospital on its foundations until it finally broke free, swirling around and around through the sky.
"TO THE MOOOOOOOOOOOOONNNNAAAAHHHHHH!!!!" Princess Celestia cried down from the sun, and Twilight Sparkle cringed.
"But I thought you loved me!" she screamed back. "You tutored and cared for me all these years! You made me a Princess! You said you were proud of me!"
Sweetie Belle squeaked out something whiny and pathetic, but nopony cared.
"MOOOOOOOOOOOONNNN!" Celestia roared again. The hospital twirled into the sky, higher and higher, and some of the elderly patients died of the bends from the sudden pressure change before Twilight managed to put a shield around the building to prevent further damage. That didn't stop it from being sent tumbling through space until, with a crash, it impacted the surface of the moon. The dust cloud it sent up was observed from as far away as Earth, where government astronomers excitedly began to plan an expedition to the first inhabited world ever discovered, completely ignoring that all traces of civilization would be erased by time before any spacegoing vessel ever made it there.
Twilight Sparkle was confused, because everypony began to pass out from asphyxiation. As the Princess of Autism, she had no idea that her ability to breathe vacuum didn't mean anypony but another Princess could do the same.
"Need... air..." Sweetie Belle whimpered. Twilight rolled her eyes.
"Oh, shush. Everything's fine, I just need to find a way to get us back to Equestria and overthrow my pissy old teacher." It was only weeks later, when the rot in the bodies of all the patients, staff, and guests became smellier than she could bear, that she let down her shield, realizing everypony else was dead.
"Well, fuck. I'm a bad student. I guess I deserve to stay here for a thousand years, just like Luna."
And they all lived happily ever after.