#1. Let's do a spike one instead. What if Spike the Dragon was not hatched by Twilight Sparkle? What If instead Spike was hacked by Zecora? What would spikes life be like instead? Would Spike the Dragon being grossed in zebra culture and start talking in rhyme? What do you have Tribal paint marks all over his body? How different would the story go? And how would the Mane 6 reaction be towards Spike when they meet him?
#2. Let's do a zephyr Breeze. What if the Zephyr Breeze was supportive of Fluttershy instead of being self-absorbed? What if Zephyr Breeze was a bit overprotective of his family instead of himself? What if Zephyr Breeze was an asexual instead of flirting with Rainbow Dash? How different would Fluttershy's life be if that happened? How different would Rainbow Dash be towards him? How would the story go and how different would Cannon be?
#3. Let's do Scootaloo. What if Scootaloo parents we're actually from Canterlot? What if Scootaloo ran away to her aunt to get away from it all? What would happen if Ponyville was actually a safe haven for her? What is she hid that she was from Canterlot? How would the story go? What difference would it make to cannon? And if it was revealed how would the cmc and others react?