In response to threats of a griffon attack on Equestria, Twilight responds with a letter detailing just why such actions would prove unfavorable for them.

The Alicorn Amulet twists its wearer into madness and megalomania. Nopony can wear it without repercussions, both for themselves and others. Nopony is safe. Nopony is exempt.

Still, nopony expected him.

The Human race is dead and gone, but their Skeletons live on in Celestia's closet.