I started out just wanting to paste that image of a vaguely unnerving Twilight Sparkle mask onto a screenshot from Venture Bros. Somehow it turned into this big honking thing, with a whole lot of the sort of Photoshopping that puts much effort into producing something that looks rather pedestrian, such as the fact that the original screenshots all had the Adult Swim tag in the lower corner.
Linked instead of inserted because it's a big image. Warning: technically contains some spoilerage for season 4 of Venture Bros. Also unlikely to make a whole lot of sense if you haven't seen the scene in question.
tl;dr: Creepy Twilight Sparkle mask is creepy.