The ponies of Equestria have always looked to the stars for guidance—and there's a very good reason for that. Back in ancient times, when the three pony tribes first united together under the Equestrian flag, the stars weren't just their guides. They were their guardians.
They were the Zodiac, twelve immortal ponies endowed with preternatural powers reaching far beyond those of a normal stallion or mare. For centuries, they served as the first, last, and best line of defense for ponykind. But when an immensely powerful foe threatens to destroy not only the newly formed nation of Equestria, but the immutable institution of the Zodiac itself, the patron saints of the stars above have their work cut out for them. With the fate of the entire world in their hooves, aspiring Hunter Leo and the rest of her super-powered friends can't afford to fail. Luckily for the mortals down below, though, that's exactly the way they like things.
After all, those vicious beasts and demons of Hades aren't about to slay themselves.