Fluttershy life had been change forever ever since she had that spell that turn her into a vampire. Even though her friends have turn her back to normal or so they thought they did. Time has passed, now Fluttershy see the time just go by and her friends passed away all but one, Twilight Sparkle. Yet the both don't get to each other much since the last of their good friend passed away.
Time has when on, Fluttershy still living in the same place. All the new generation of ponies in ponyville tell each other to "do not go there. A vampire lived there."
See that things are going to be like that for her only made her depressed.
Will somepony give her the chance and see she still the same pony from before, or they try to kill her for thinking she is evil. Only time can tell.